Safeguarding Genetic Integrity for Preclinical Research with Rodent Models: Processes and Technologies - Part 2
In part two of this webinar series, we will dive deeper into a wide range of genetic monitoring strategies. Gain a deeper understanding of the use of coat color and physical observations as a low-tech monitoring strategy, selecting physical colony location based on risk factors such as coat color, strain background, and gene of interest. Then, explore innovative strategies, including transgene sequencing, monitoring of transgene integrity via copy number and expression testing, monitoring observations, and whole genome sequencing (WGS) in inbred strain refreshes or identification of spontaneous mutations.
Are you taking the necessary steps to safeguard the genetic integrity of your breeding colonies? Learn how to mitigate the impact of genetic integrity disruptions and identify and manage off-target mutations resulting from CRISPR-mediated gene editing.
Dr. Smits will introduce the Taconic AWARE™ program, the first program in the industry to proactively assess and score GEM projects based on a number of parameters, including genetic risk and adverse phenotypes. Don't miss out on part two of this webinar series.
Attend this webinar to learn about:
Strategies to assess and stabilize genetic background of GEM lines
Selecting the most appropriate strategy for genetic monitoring based on mutation type
How transgene expression can change over time and strategies to prevent this change
Practical tips to optimize genetic integrity for CRISPR-based projects